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| Palermo,A.M; Mudry,M.D. |
| Acetaldehyde (AAld) is a ubiquitous compound in the environment. Exposure may occur in its manufacture or use, in the consumption of alcoholic beverages and through cigarette smoke. It causes distant target effects, including DNA damage, glutathione depletion, enzyme inactivation and cell death. In the present work, its potential teratogenic, mutagenic and recombinagenic effects in somatic cells of D. melanogaster were analyzed. The white/white+ (w/w+) eye mosaic test (Somatic Mutation And Recombination Test, SMART) was applied by mating w/w females with y/Y males. Larvae of 48 ± 4 h were transferred to media with 0.01 %, 0.02 %, 0.05 % and 0.10 % AAld for 12 hs and then moved to regular media until pupation. The emerging w/w+ females were evaluated for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ethanol; Teratogenesis; Mutagenesis; Loss of heterozygosity; Eye-spot test. |
| Ano: 2015 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332015000300007 |
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| Andrioli,N.B; Chaufan,G; Coalova,I; Ríos de Molina,M.C; Mudry,M.D. |
| Early detection of toxic events induced by xenobiotics is necessary for a proper assessment of human risk after the exposure to those agents. The aim of this work was to evaluate the cell line HEp-2 as an experimental model to determine the genotoxic effects of sodium arsenate. To this end, we determined the metabolic activity cells by the MTT test on seven concentrations of arsenate that range from 27 to 135,000 μM, obtaining the median lethal concentration (LC50), the lowest observed effect concentration (LOEC), and the not observed effect concentration (NOEC) of sodium arsenate at 24 h of exposition. According to the cytotoxic response obtained, we evaluated the genotoxic effect of the 27 and 270 μM concentrations by using the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cytotoxicity; Genotoxicity; Glutathione; HEp-2 cell line. |
| Ano: 2017 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332017000300002 |
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| Giudice,A.M; Bruno,G.; Mudry,M.D. |
| Los primates mantenidos en cautiverio, evidencian la necesidad de estimular su comportamiento natural y de promover su bienestar. Esta contribución describe los cambios en los marcadores etológicos en Cebus libidinosus (CLI) juveniles (1 macho y 2 hembras) mantenidos en cautiverio (ECAS, Berazategui, Argentina), bajo dos condiciones de alojamiento. Se utilizó el muestreo de barrido. Se evaluó la conducta "locomoción estereotipada". El tiempo total de observación fue de 290 horas. El nivel de locomoción estereotipada descendió y la jeraquía social se modifico. CLI mantenidos en cautiverio muestran: incremento en el comportamiento de interacción ambiente físico-social luego del cambio de recinto y la frecuencia de locomoción estereotipada se relacionó con... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cebus libidinosus; Cautiverio; Marcadores etológicos. |
| Ano: 2011 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-34982011000100010 |
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